Abstract

 

Background: Malignant pleural effusion (MPE) is the lethal consequence of various human cancers. No effective agents are currently available to cure MPE. Para-toluenesulfonamide (PTS) is a small molecule and was reported to demonstrate potential activity in treating lung cancer. To assess the safety and efficacy of PTS for treating MPE, we conducted a study using intrapleural PTS injections in mice. To validate the findings, we further conducted a single-arm exploratory study, using PTS to treat MPE in lung cancer patients.